Abstract Programmable RNA editing is harnessed for modifying mRNA.Besides mRNA, miRNA also regulates numerous biological activities, but current RNA editors have yet to be exploited for miRNA manipulation.To engineer primary miRNA (pri-miRNA), the miRNA precursor, we present a customizable editor REPRESS (RNA Editing of Pri-miRNA for Efficient Supp
This paper explores the gradual change of direction in the European digital policy on the content layer that took place after the Ceramic Plant Pot introduction of the 2015 Digital Single Market Strategy.It argues that, while the main objectives of the pre2015 policy have been the promotion and facilitation of the free movement of digital services
Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy.We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered alone or in combination with carboplatin.Olaparib acts by inhibiting PARP-dependent repair pathways